A new 5α, 8α-epidioxysterol with immunosuppressive activity from the South China Sea soft coral Sinularia sp. Issue 13 (2nd July 2020)

• Record Type: Journal Article
• Authors: Yang, Min; Liang, Lin-Fu; Li, Heng; Tang, Wei; Guo, Yue-Wei
• Is Part Of: Natural product research. Volume 34:Issue 13(2020)
• Page Start: 1814
• Page End: 1819
• Publication Date: 2020-07-02
• Subjects: Immunosuppressive activity -- Soft coral -- Sinularia sp. -- 5α, 8α-Epidioxysterol -- Yalongsterol A; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1561683
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new 5α, 8α-epidioxysterol, namely yalongsterol A (1 ), along with two known related steroids 5α, 8α-epidioxy-24-methyl-cholesta-6, 24(28)-dien-3β-ol (2 ) and (22 E, 24 S )-5α, 8α-epidioxy-24-methyl-cholesta-6, 22-dien-3β-ol (3 ), were isolated from the South China Sea soft coral Sinularia sp. Their structures were established by extensive spectroscopic analyses and comparisons of the spectral data with those reported in the literature. In bioassay, compounds 1 –3 showed moderate immunosuppressive activities against T and/or B lymphocyte cells with IC50 values ranging from 19.30 to 59.49 μ M, and low cytotoxicity on murine splenocytes with CC50 values ranging from 40.88 to 62.29 μ M.