The metabolic and endocrine response to trauma. Issue 8 (August 2020)

• Record Type: Journal Article
• Authors: Krepska, Amy; Hastings, Jennifer; Roodenburg, Owen
• Is Part Of: Anaesthesia and intensive care medicine. Volume 21:Issue 8(2020)
• Page Start: 417
• Page End: 421
• Publication Date: 2020-08
• Subjects: Catecholamines -- coagulation -- cortisol -- enhanced recovery pathway -- fibrinogen -- gluconeogenesis -- glutamine -- hypothalamic pituitary axis -- inflammatory mediators -- regional anaesthesia -- renin angiotensin aldosterone system -- transfusion; Anesthesiology -- Periodicals; Critical care medicine -- Periodicals; Anesthesia -- Periodicals; Intensive care -- Periodicals; Electronic journals; Periodicals; 617.9605
• DOI: 10.1016/j.mpaic.2020.04.011
• Languages: English
• ISSNs: 1472-0299

Abstract

Abstract: Metabolic and endocrine pathways are central to the body's compensatory response to trauma. They drive mobilization of energy substrates, volume conservation and haemostasis via activation of the hypothalamic pituitary adrenal axis, the sympathetic nervous system and an inflammatory response. As clinicians, we can intervene in these pathways, however optimal management of anaesthesia, fluids, transfusion, nutrition and the use of steroids remains controversial and to be determined.