A case of ALK-rearranged lung adenocarcinoma associated with syndrome of inappropriate antidiuretic hormone. (2020)

• Record Type: Journal Article
• Authors: Miyashita, Yoshihiro; Hanawa, Kotaro; Kobayashi, Hiroaki; Kumagai, Takashi; Inomata, Kie; Tsutsui, Toshiharu; Kakizaki, Yumiko; Oyama, Toshio
• Is Part Of: Respiratory medicine case reports. Volume 30(2020)
• Publication Date: 2020
• Subjects: ALK -- SIADH -- Hyponatremia -- Crizotinib -- Lung adenocarcinoma; Respiratory organs -- Diseases -- Periodicals; Chest -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Respiratory System -- Periodicals; Chest -- Diseases; Respiratory organs -- Diseases; Electronic journals; Periodicals; 616.2
• DOI: 10.1016/j.rmcr.2020.101136
• Languages: English
• ISSNs: 2213-0071

Abstract

Abstract: A 60-year-old man with a history of smoking was transferred to our hospital for consciousness disorder. A diagnosis of ALK- rearranged lung adenocarcinoma associated with a paraneoplastic electrolytic disorder was made following a cutaneous needle biopsy. Both the primary lung lesion and multiple metastases shrunk and his electrolytic disorder resolved after the introduction of a first-line molecular-targeted drug chemotherapy with crizotinib. We herein report a case of ALK -rearranged lung adenocarcinoma accompanied by SIADH, successfully treated with crizotinib.