A case of ROS1-rearranged lung adenocarcinoma with osteoblastic bone metastasis. (2020)

• Record Type: Journal Article
• Authors: Takahara, Yutaka; Yamamura, Kouichi; Matsuura, Saki; Sakuma, Takashi; Nishiki, Kazuaki; Nakase, Keisuke; Nojiri, Masafumi; Kato, Ryo; Shinomiya, Shohei; Oikawa, Rieko; Fujimoto, Yuki; Oikawa, Taku; Osanai, Kazuhiro; Ueda, Yoshimichi; Mizuno, Shiro
• Is Part Of: Respiratory medicine case reports. Volume 30(2020)
• Publication Date: 2020
• Subjects: Osteoblastic bone metastases -- ROS1-Rearranged lung adenocarcinoma; Respiratory organs -- Diseases -- Periodicals; Chest -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Respiratory System -- Periodicals; Chest -- Diseases; Respiratory organs -- Diseases; Electronic journals; Periodicals; 616.2
• DOI: 10.1016/j.rmcr.2020.101124
• Languages: English
• ISSNs: 2213-0071

Abstract

Abstract: A 53-year-old woman was referred to our hospital for detailed examination of abnormal chest shadows recognized on CT imaging. Transbronchial lung biopsy of a right S6 nodular shadow led to a diagnosis of lung adenocarcinoma. FDG-PET-CT showed FDG accumulation in the Th11 and L2 vertebral bodies and osteoblastic bone lesions. Since osteoblastic bone metastasis in lung cancer is extremely rare, CT-guided bone biopsy was performed. The tumor was diagnosed as ROS1-rearranged lung adenocarcinoma, for which crizotinib was administered, which led to improvement of both the primary and metastatic lesions. We report here a rare case of ROS1-rearranged lung adenocarcinoma with osteoblastic bone metastasis of lung cancer.