Chitosan/PVA hydrogels incorporated with green synthesized cerium oxide nanoparticles for wound healing applications. (5th July 2020)

• Record Type: Journal Article
• Authors: Kalantari, Katayoon; Mostafavi, Ebrahim; Saleh, Bahram; Soltantabar, Pooneh; Webster, Thomas J.
• Is Part Of: European polymer journal. Volume 134(2020)
• Publication Date: 2020-07-05
• Subjects: Chitosan -- Wound healing -- CeO2 nanoparticles -- Hydrogel -- Human dermal fibroblasts -- Antibacterial -- MRSA; Polymers -- Periodicals; Polymerization -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; Polymerization; Polymers; Periodicals; Electronic journals; 547.705
• DOI: 10.1016/j.eurpolymj.2020.109853
• Languages: English
• ISSNs: 0014-3057

Abstract

Graphical abstract: Highlights: CeO2 -NPs synthesized using the Zingiber officinale extract as a green method. CeO2 -NPs were coated with an organic leaf extract forming small aggregates. PVA/chitosan hydrogel loaded with CeO2 -NPs evaluated for potential wound dressing. Hydrogels showed enhanced cell compatibility and survival with addition of CeO2 -NPs. Hydrogels showed potent antibacterial activity against MRSA. Abstract: In this paper, we report the synthesis and evaluation of a polyvinyl alcohol/chitosan (PVA/chitosan) hydrogel incorporated with green synthesized cerium oxide nanoparticles (CeO2 -NPs) using a Zingiber officinale extract as the reducing, capping and stabilizer agent for wound healing applications. The PVA/chitosan/CeO2 -NPs hydrogel was synthesized via the freeze-thaw technique with 0 to 1% (wt) 5 nm CeO2 -NPs. Results revealed that the hydrogels containing 0.5% of CeO2 -NPs showed better antibacterial activities after just 12 hr (with MRSA but not E. coli ) and healthy human dermal fibroblast viabilities up to 5 days (more than 90%) compared to the control group. Therefore, these chitosan/PVA hydrogels incorporated with Ce-NPs could be a potential candidate as a robust wound dressing agent that impressively may decrease wound infections without resorting to the use of antibiotics.