Transient cortical diffusion restriction in children immediately after prolonged febrile seizures. (July 2020)

• Record Type: Journal Article
• Authors: Suzuki, Takeshi; Kidokoro, Hiroyuki; Kubota, Tetsuo; Fukasawa, Tatsuya; Suzui, Ryosuke; Tsuji, Takeshi; Kato, Toru; Yamamoto, Hiroyuki; Ohno, Atsuko; Nakata, Tomohiko; Saitoh, Shinji; Okumura, Akihisa; Natsume, Jun
• Is Part Of: European journal of paediatric neurology. Volume 27(2020)
• Page Start: 30
• Page End: 36
• Publication Date: 2020-07
• Subjects: Prolonged febrile seizure -- Diffusion weighted image -- Cortex; Pediatric neurology -- Periodicals; Nervous System Diseases -- Periodicals; Child -- Periodicals; Infant -- Periodicals; Neurologie pédiatrique -- Périodiques; Pediatric neurology; Electronic journals; Periodicals; Electronic journals; 618.928
• DOI: 10.1016/j.ejpn.2020.05.004
• Languages: English
• ISSNs: 1090-3798

Abstract

Abstract: Aim: Little is known about acute febrile status epilepticus-induced injury of extrahippocampal structures. To clarify the presence and clinical significance of acute extrahippocampal injuries, we performed diffusion-weighted imaging (DWI) in children immediately after prolonged febrile seizure (PFS). Method: We performed a retrospective cohort study in children younger than 6 years old who visited one of two hospitals due to PFSs between January 2013 and October 2018. PFS was defined as a febrile seizure that persisted for 15 min or longer. We collected brain DWI data within 6 h of the end of PFS. When the initial DWI detected an abnormality, a follow-up DWI was performed a few days later. Results: The study population consisted of 101 patients with PFSs. DWI was performed within 6 h in 51 patients, while the remaining 50 patients did not undergo imaging because of good recovery of consciousness. Restricted cortical diffusion was evident in 9 (18%) patients on initial DWI. All of them underwent DWI within 100 min after PFS. Restricted cortical diffusion was associated with male sex, asymmetrical PFS symptoms, and a shorter duration between the end of the seizure and DWI, but was not associated with seizure duration. All cortical abnormalities had resolved on follow-up DWI of these patients within 72 h after the initial imaging, but ipsilateral hippocampal hyperintensity appeared in one patient. All 9 patients with restricted cortical diffusion were finally diagnosed with PFS and discharged without sequelae. Conclusions: Some children with PFSs exhibit transient restricted diffusion in the regional cortex on DWI performed immediately after the end of PFS. These transient diffusion changes were not associated with unfavorable epileptic sequelae or neuroimaging in the short-term. Highlights: We studied diffusion-weighted imaging (DWI) within 6 h after prolonged febrile seizures in 51 patients. Restricted cortical diffusion was evident in nine (18%) patients. On follow-up imaging, restricted cortical diffusion had resolved in all nine patients. None of nine patients with restricted cortical diffusion on initial imaging manifested short-term neurological sequelae.