Knowledge gaps in oncoplastic breast surgery. Issue 8 (August 2020)

• Record Type: Journal Article
• Authors: Weber, Walter P; Morrow, Monica; Boniface, Jana de; Pusic, Andrea; Montagna, Giacomo; Kappos, Elisabeth A; Ritter, Mathilde; Haug, Martin; Kurzeder, Christian; Saccilotto, Ramon; Schulz, Alexandra; Benson, John; Fitzal, Florian; Matrai, Zoltan; Shaw, Jane; Peeters, Marie-Jeanne Vrancken; Potter, Shelley; Heil, Joerg; Eduardo, González; Mona, Elzayat; Rupert, Koller; Michael, Gnant; Fabricio, Brenelli; Regis Resende, Paulinelli; Vappu, Zobel; Sarianna, Joukainen; Ulla, Karhunen-Enckell; Susanna, Kauhanen; Jean-Marc, Piat; Vesna, Bjelic-Radisic; Andree, Faridi; Christoph, Heitmann; Juergen, Hoffmann; Ulrich, Kneser; Sherko, Kümmel; Thorsten, Kühn; Michalis, Kontos; Ekaterini Christina, Tampaki; Mitchel, Barry; Tanir M, Allweis; Moshe, Carmon; Tal, Hadar; Giuseppe, Catanuto; Carlos A, Garcia-Etienne; Oreste D, Gentilini; Susan, Knox; Barbara, Klein; Linetta, Koppert; Pedro F, Gouveia; Tor, Svensjö; Heiner C, Bucher; Silvia, Ess; Ursula, Ganz-Blättler; Andreas, Günthert; Nik, Hauser; Nancy, Hynes; Michael, Knauer; Marlen, Pfeiffer; Christoph, Rochlitz; Christoph, Tausch; Yves, Harder; Frank, Zimmermann; Fabienne D, Schwab; Veronica, D'Amico; Savas D, Soysal; Liliana, Castrezana Lopez; Ilario, Fulco; Lars G, Hemkens; Visnu, Lohsiriwat; Bahadir M, Gulluoglu; Guldeniz, Karadeniz; Hasan, Karanlik; Atakan, Sezer; Mehmet Ali, Gulcelik; Mustafa, Emiroglu; Tibor, Kovacs; Tim, Rattay; Laszlo, Romics; Raghavan, Vidya; Lynda, Wyld; Mahmoud, El-Tamer; Virgilio, Sacchini;
• Is Part Of: Lancet oncology. Volume 21:Issue 8(2020)
• Page Start: e375
• Page End: e385
• Publication Date: 2020-08
• Subjects: Oncology -- Periodicals; Neoplasms -- Periodicals; Cancérologie -- Périodiques; Oncologie; Oncology; Periodicals; Electronic journals; 616.994005
• DOI: 10.1016/S1470-2045(20)30084-X
• Languages: English
• ISSNs: 1470-2045

Abstract

Abstract: The aims of the Oncoplastic Breast Consortium initiative were to identify important knowledge gaps in the field of oncoplastic breast-conserving surgery and nipple-sparing or skin-sparing mastectomy with immediate breast reconstruction, and to recommend appropriate research strategies to address these gaps. A total of 212 surgeons and 26 patient advocates from 55 countries prioritised the 15 most important knowledge gaps from a list of 38 in two electronic Delphi rounds. An interdisciplinary panel of the Oncoplastic Breast Consortium consisting of 63 stakeholders from 20 countries obtained consensus during an in-person meeting to select seven of these 15 knowledge gaps as research priorities. Three key recommendations emerged from the meeting. First, the effect of oncoplastic breast-conserving surgery on quality of life and the optimal type and timing of reconstruction after nipple-sparing or skin-sparing mastectomy with planned radiotherapy should be addressed by prospective cohort studies at an international level. Second, the role of adjunctive mesh and the positioning of implants during implant-based breast reconstruction should ideally be investigated by randomised controlled trials of pragmatic design. Finally, the BREAST-Q questionnaire is a suitable tool to assess primary outcomes in these studies, but other metrics to measure patient-reported outcomes should be systematically evaluated and quality indicators of surgical morbidity should be further assessed.