Antiproliferative diterpenoids and acetophenone glycoside from the roots of Euphorbia fischeriana. (September 2020)

• Record Type: Journal Article
• Authors: Du, Kaicheng; Yang, Xinyong; Li, Jiaheng; Meng, Dali
• Is Part Of: Phytochemistry. Volume 177(2020)
• Publication Date: 2020-09
• Subjects: Euphorbia fischeriana Steud -- Euphorbiaceae -- Diterpenoid -- Acetophenone glycoside -- Antiproliferation; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2020.112437
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Three undescribed compounds and nine known compounds were isolated from the Euphorbia fischeriana Steud. Their structures were elucidated by extensive analysis of the 1D and 2D NMR spectra and HRESIMS data. The absolute configurations of two undescribed diterpenoids were determined by comparing their experimental and calculated ECD data. To further understand the antitumor effects of E. fischeriana, we tested the antiproliferative activities of these compounds against AGS, Hep-G2 cell lines in vitro using CCK-8 assays. The results showed that both types of compounds had significant antiproliferative effects, among which a diterpenoid with a galloyl moiety (IC50 = 7.03 μM) was the most significant one that could be regarded as a potential leading compound against liver cancer for further comprehensive study. Graphical abstract: Image 1 Highlights: Three undescribed compounds were isolated from the Euphorbia fischeriana Steud. The antiproliferative activity of isolated compounds was tested in vitro . Some preliminary structure-activity analyses are presented.