Intranasal octenidine and universal chlorhexidine bathing can reduce meticillin-resistant Staphylococcus aureus acquisition in an extended care facility in Singapore. Issue 4 (August 2020)

• Record Type: Journal Article
• Authors: Chow, A.; Wong, J.; Zhang, W.; Poh, B.-F.; Ang, B.
• Is Part Of: Journal of hospital infection. Volume 105:Issue 4(2020)
• Page Start: 628
• Page End: 631
• Publication Date: 2020-08
• Subjects: Chlorhexidine bathing -- Intranasal octenidine -- MRSA acquisition -- Extended care facility; Cross infection -- Periodicals; Cross infection -- Prevention -- Periodicals; Nosocomial infections -- Periodicals; Nosocomial infections -- Prevention -- Periodicals; Cross Infection -- Periodicals; Cross Infection -- prevention & control -- Periodicals; Infection Control -- Periodicals; Electronic journals; 614.44
• DOI: 10.1016/j.jhin.2020.04.030
• Languages: English
• ISSNs: 0195-6701

Abstract

Summary: Meticillin-resistant Staphylococcus aureus (MRSA) is prevalent in extended care facilities. We conducted a quasi-experimental before–after study in a 100-bed rehabilitation hospital, from January 2013 to June 2019. Universal chlorhexidine bathing was implemented throughout the period, with intranasal octenidine for MRSA colonizers added from September 2017. Interrupted time-series with segmented regression analysis revealed that after adjusting for at-admission MRSA colonization and hand hygiene compliance, a constant trend was observed pre implementation of intranasal octenidine (adjusted mean coefficient: 0.012; 95% confidence interval: –0.037 to 0.06), with an immediate decrease with implementation (–2.145; –0.248 to –0.002; P = 0.033), followed by a significant reduction in MRSA acquisition post implementation (–0.125; –0.248 to –0.002; P = 0.047).