Aortic root replacement to treat type A aortic dissection: A comparison of midterm outcomes between composite valve grafts and porcine aortic roots. Issue 8 (9th July 2020)

• Record Type: Journal Article
• Authors: Salmasi, Mohammad Yousuf; Panda, Abinash; Hartley, Philip; Abdulkhader, Ashiq; Osman, Ahmed; Nienaber, Christoph; Athanasiou, Thanos; Asimakopoulos, George
• Is Part Of: Journal of cardiac surgery. Volume 35:Issue 8(2020)
• Page Start: 1840
• Page End: 1847
• Publication Date: 2020-07-09
• Subjects: aorta -- great vessels; Heart -- Surgery -- Periodicals; 617.412005
• DOI: 10.1111/jocs.14712
• Languages: English
• ISSNs: 0886-0440

Abstract

Abstract: Background: Porcine aortic roots (PAR) have been reported in the literature with acceptable short‐ and long‐term outcomes for the treatment of aortic root aneurysms. However, their efficacy in type A aortic dissection (TAAD) is yet to be defined. Methods: Using data from a locally collated aortic dissection registry, we compared the outcomes in patients undergoing aortic root replacement for TAAD using either of two surgical options: (a) PAR or (b) composite valve grafts (CVG). A retrospective analysis was conducted for all procedures in the period from 2005 to 2018. Results: A total of 252 patients underwent procedures for TAAD in the time period. Sixty‐five patients had aortic root replacements (PAR n = 30, CVG n = 35). Between‐group comparisons identified a younger CVG group (50.5 vs 64.5, P < .05) although all other covariates were comparable. Operative parameters were comparable between the two groups. The use of PAR did not significantly impact operative mortality (odds ratio [OR], 0.93; 95% confidence interval [CI], 0.22‐3.61; P = .992), stroke (OR, 2.91, 0.25‐34.09, P = .395), reoperation (OR, 0.91; 95% CI, 0.22‐3.62; P = .882) or length of stay (coeff 2.33, −8.23 to 12.90; P = .659) compared to CVG. Five‐year survival was similar between both groups (PAR 59% vs CVG 69%; P = .153) and reoperation was negligible. Echocardiography revealed significantly lower aortic valve gradients in the PAR group (8.69 vs 15.45mm Hg; P < .0001), and smaller left ventricular dimensions both at 6‐week and 1‐year follow‐up ( P < .05). Conclusions: This study highlights the comparable short‐ and midterm outcomes of PAR in cases of TAAD, in comparison to established therapy.