Surface Modification of Luminescent LnIII Fluoride Core–Shell Nanoparticles with Acetylsalicylic acid (Aspirin): Synthesis, Spectroscopic and in Vitro Hemocompatibility Studies. (24th June 2020)

• Record Type: Journal Article
• Authors: Kwiatek, Dorota; Mrówczyńska, Lucyna; Stopikowska, Natalia; Runowski, Marcin; Lesicki, Andrzej; Lis, Stefan
• Is Part Of: ChemMedChem. Volume 15:Number 15(2020)
• Page Start: 1490
• Page End: 1496
• Publication Date: 2020-06-24
• Subjects: aspirin -- blood contacting applications -- human erythrocytes -- luminescent nanoparticles -- surface-modified core-shell NPs; Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.202000269
• Languages: English
• ISSNs: 1860-7179

Abstract

Abstract: Luminescent lanthanide fluoride core–shell (LaF3 :Tb 3+, Ce 3+ @SiO2 ‐NH2 ) nanoparticles, with acetylsalicylic acid (aspirin) coated on the surface have been obtained. The synthesized products, which combine the potential located in the silica shell with the luminescent activity of the core, were characterized in detail with the use of luminescence spectroscopy, Fourier transform infrared spectroscopy (FTIR), X‐ray diffraction (XRD), and transmission electron microscopy (TEM) methods. The in vitro effects of the modified luminescent nanoparticles on human red blood cell (RBC) membrane permeability, RBC shape, and sedimentation rate were investigated to assess the hemocompatibility of the obtained compounds. This study demonstrates that LaF3 : Tb 3+ 5 %, Ce 3+ 10 %@SiO2 ‐NH2 nanoparticles with acetylsalicylic acid (aspirin) coated on the surface are very good precursors for multifunctional drug‐delivery systems or bio‐imaging probes that can be used safely in potential biomedical applications. Abstract : As mesoporous silicas are potential drug carriers, we silica shells with a luminescent core to obtain a multifunctional luminophore precursor probe: luminescent lanthanum(III) fluoride core‐shell nanoparticles with aspirin loaded on the surface. Based on hemocompatibility assays, the nanoparticles neither induce changes in the structure of the red blood cell (RBC) membrane nor significantly affect the RBC sedimentation rate.