Circulating microRNA changes in patients with impaired glucose regulation. (1st January 2020)

• Record Type: Journal Article
• Authors: Fachim, Helene A.; Loureiro, Camila M.; Siddals, Kirk; Dalton, Caroline F; Reynolds, Gavin P.; Gibson, J. Martin; Chen, Zhen Bouman; Heald, Adrian H.
• Is Part Of: Adipocyte. Volume 9:Number 1(2020)
• Page Start: 443
• Page End: 453
• Publication Date: 2020-01-01
• Subjects: Circulating microRNAs -- pre-diabetes -- impaired glucose regulation (IGR) -- lifestyle change; Fat cells -- Periodicals; Adipocytes -- Periodicals; 611.018276
• DOI: 10.1080/21623945.2020.1798632
• Languages: English
• ISSNs: 2162-3945

Abstract

ABSTRACT: We analysed if levels of four miRNAs would change after a lifestyle intervention involving dietary and exercises in prediabetes. MiRNAs previously shown to be associated with diabetes (Let-7a, Let-7e, miR-144 and miR-92a) were extracted from serum pre- and post-intervention. mRNA was extracted from fat-tissue for gene expression analyses. The intervention resulted in increased Let-7a and miR-92a. We found correlations between miRNAs and clinical variables (triglycerides, cholesterol, insulin, weight and BMI). We also found correlations between miRNAs and target genes, revealing a link between miR-92a and IGF system. A lifestyle intervention resulted in marked changes in miRNAs. The association of miRNAs with insulin and the IGF system (both receptors and binding proteins) may represent a mechanism of regulating IGFs metabolic actions.