VDAC and its interacting partners in plant and animal systems: an overview. (3rd July 2020)

• Record Type: Journal Article
• Authors: Kanwar, Poonam; Samtani, Harsha; Sanyal, Sibaji K.; Srivastava, Ashish K.; Suprasanna, Penna; Pandey, Girdhar K.
• Is Part Of: Critical reviews in biotechnology. Volume 40:Number 5(2020)
• Page Start: 715
• Page End: 732
• Publication Date: 2020-07-03
• Subjects: Apoptosis -- cancer -- development -- ions -- diseases -- oligomerization -- signaling -- stress -- VDAC -- mitochondria; Biotechnology -- Periodicals; Biotechnology -- Periodicals; Review Literature -- Periodicals; Public Health -- Periodicals; Environment -- Periodicals; Industry -- Periodicals; Biotechnology; Review Literature; Public Health; Environment; Industry; 660.6
• DOI: 10.1080/07388551.2020.1756214
• Languages: English
• ISSNs: 0738-8551

Abstract

Abstract: Molecular trafficking between different subcellular compartments is the key for normal cellular functioning. Voltage-dependent anion channels (VDACs) are small-sized proteins present in the outer mitochondrial membrane, which mediate molecular trafficking between mitochondria and cytoplasm. The conductivity of VDAC is dependent on the transmembrane voltage, its oligomeric state and membrane lipids. VDAC acts as a convergence point to a diverse variety of mitochondrial functions as well as cell survival. This functional diversity is attained due to their interaction with a plethora of proteins inside the cell. Although, there are hints toward functional conservation/divergence between animals and plants; knowledge about the functional role of the VDACs in plants is still limited. We present here a comparative overview to provide an integrative picture of the interactions of VDAC with different proteins in both animals and plants. Also discussed are their physiological functions from the perspective of cellular movements, signal transduction, cellular fate, disease and development. This in-depth knowledge of the biological importance of VDAC and its interacting partner(s) will assist us to explore their function in the applied context in both plant and animal.