BMP2 variants in the risk of ankylosing spondylitis. Issue 8 (12th November 2019)

• Record Type: Journal Article
• Authors: Qi, Dengbin; Tian, Xiaodong; Wang, Yan; Zheng, Guoquan; Zhang, Xuesong
• Is Part Of: Journal of cellular biochemistry. Volume 121:Issue 8/9(2020)
• Page Start: 3935
• Page End: 3940
• Publication Date: 2019-11-12
• Subjects: ankylosing spondylitis -- BMP2 -- polymorphism -- susceptibility; Cytochemistry -- Periodicals; 572
• DOI: 10.1002/jcb.29563
• Languages: English
• ISSNs: 0730-2312

Abstract

Abstract: The purpose of the study was to explore the genetic effects of bone morphogenetic protein ( BMP2 ) polymorphisms on the susceptibility to ankylosing spondylitis (AS) in Chinese Han population. The case‐control study included 120 AS cases and 110 healthy controls. Hardy‐Weinberg equilibrium test was performed in control group. BMP2 rs235768 and rs3178250 polymorphisms were analyzed by polymerase chain reaction and direct sequencing. Additionally, the χ 2 test was used to estimate association strength between BMP2 genetic polymorphisms and AS susceptibility, and the results were assessed via odds ratio (OR) with the corresponding 95% confidence interval (95%CI). Results adjustment was performed using logistic regression analysis. AA, AT, TT genotype and A, T allele frequencies of BMP2 rs235768 polymorphism presented no significant differences between case and control groups ( P > .05 for all). TC genotype of rs3178250 polymorphism showed significantly higher in case group than that in control group ( P = .048). After adjusting, TC genotype was a risk factor for AS (OR = 2.095; 95%CI = 1.086‐4.038; P = .027). BMP2 rs3178250 polymorphism may increase individual susceptibility to AS in Chinese Han population. Abstract : In conclusion, bone morphogenetic protein rs3178250 polymorphism may be positively associated with the individual susceptibility to ankylosing spondylitis (AS) in Chinese Han population, and TC genotype may contribute to AS development.