Synthesis and Versatile Utilization of 2‐Pyridyl and Pyrimidyl‐Related Reagents. (8th July 2020)

• Record Type: Journal Article
• Authors: In Lee, Jae
• Is Part Of: Bulletin of the Korean Chemical Society. Volume 41:Number 7(2020)
• Page Start: 735
• Page End: 747
• Publication Date: 2020-07-08
• Subjects: Acylation -- Alkoxycarbonylation -- Dehydration -- Dehydrosulfurization -- (Thio)carbonyl transfer; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/bkcs.12061
• Languages: English
• ISSNs: 0253-2964

Abstract

Abstract : Active (thio)esters and amides were prepared from carboxylic acids and several reagents containing 2‐pyridyl or pyrimidyl moiety. Active (thio)carbonates, thionocarbonate, and thiourea were prepared from (thio)phosgene and 2‐hydroxypyridine or 2‐mercaptopyridine. The acylation of active (thio)esters and amides containing 2‐pyridyl or pyrimidyl groups with various organometallics afforded ketones, aldehydes, esters, amides, and β‐keto esters. The alkoxycarbonylation of active (thio)carbonates with Grignard reagents and amines afforded esters and carbamates, respectively. Active di(thiono)carbonates and thiourea containing the 2‐pyridyl or pyrimidyl moiety have been used in the dehydration of carboxylic acids/alcohols or aldoximes, dehydrosulfurization of thioureas, and (thio)carbonyl transfer of diols or amines to produce esters or nitriles, carbodiimides, cyclic carbonates or isothiocyanates, respectively. Abstract : Synthesis and Versatile Utilization of 2‐Pyridyl and Pyrimidyl‐Related Reagents