Fetal hydrops – a review and a clinical approach to identifying the cause. (3rd March 2020)

• Record Type: Journal Article
• Authors: Dempsey, Esther; Homfray, Tessa; Simpson, John M; Jeffery, Steve; Mansour, Sahar; Ostergaard, Pia
• Is Part Of: Expert opinion on orphan drugs. Volume 8:Number 2/3(2020)
• Page Start: 51
• Page End: 66
• Publication Date: 2020-03-03
• Subjects: Fetal -- prenatal -- nonimmune fetal hydrops -- genomic -- exome -- lymphatic -- rasopathy -- ultrasound -- hydrops -- noninvasive prenatal diagnosis; Orphan drugs -- Periodicals; Rare diseases -- Periodicals; Chemotherapy -- Periodicals; 615.1
• DOI: 10.1080/21678707.2020.1719827
• Languages: English
• ISSNs: 2167-8707

Abstract

ABSTRACT: Introduction : Fetal hydrops describes abnormal fluid accumulation in two or more extravascular fetal compartments. It is a poor prognostic sign in a fetus, and many will not survive to term. Fetal hydrops is a clinical sign rather than a diagnosis and has a multitude of different causes. Areas covered : This review focusses on nonimmune fetal hydrops. We discuss in detail the most common etiologies such as infection and chromosomal abnormalities and cover rarer presentations of congenital malformation and single-gene disorders. We present a decision tree for the investigation of affected pregnancies. Expert opinion : The current approach to the investigation of fetal hydrops largely revolves around identifying the abnormal pathophysiology via ultrasound imaging. We believe that as genomic testing of a pregnancy can be undertaken with increasing accuracy, speed, accessibility and at reduced cost, genetic testing will feature earlier in the future diagnostic pathway.