Acute systematic inflammatory response syndrome and serum biomarkers predict outcomes after subarachnoid hemorrhage. (August 2020)

• Record Type: Journal Article
• Authors: Hokari, Masaaki; Uchida, Kazuki; Shimbo, Daisuke; Gekka, Masayuki; Asaoka, Katsuyuki; Itamoto, Koji
• Is Part Of: Journal of clinical neuroscience. Volume 78(2020)
• Page Start: 108
• Page End: 113
• Publication Date: 2020-08
• Subjects: Biomarkers -- Subarachnoid hemorrhage -- Systematic inflammatory response syndrome -- Surgical invasion; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2020.05.055
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: Subarachnoid hemorrhage (SAH) can induce systematic inflammatory response syndrome (SIRS). SIRS score was higher in patients with poor-grade SAH and predicted outcomes after SAH. SIRS score was higher with clipping than with coil embolization among patients with good-grade SAH. Abstract: Subarachnoid hemorrhage (SAH) can trigger immune activation sufficient to induce systematic inflammatory response syndrome (SIRS). Serum inflammatory biomarkers and SIRS can predict a poor outcome. The relationship between surgical stress and inflammatory response is well known but described in few reports in the neurosurgical population. We aimed to ascertain whether postoperative SIRS and initial serum biomarkers were associated with outcomes and evaluate whether the postoperative SIRS score differed between those with clipping and coil embolization. We evaluated 87 patients hospitalized within 24 h from onset of nontraumatic SAH. Serum biomarkers, such as levels of C-reactive protein (CRP), white blood cells (WBC), and D-dimer, as well as stress index (SI: blood sugar/K ratio) were obtained at admission. SIRS scores 3 days after admission were derived by adding the number of variables meeting the standard criteria (heart rate [HR] >90, respiratory rate [RR] >20, temperature >38 °C or <36 °C, and WBC count <4000 or >12, 000). Clinical variables were compared according to whether they were associated with poor outcomes. Coil embolization was performed in 30 patients and clipping in 57. WBC, SI, D-dimer levels, and SIRS scores were significantly higher in patients with poor-grade SAH and were associated with poor outcomes. SIRS scores were significantly higher with clipping than with coil embolization among patients with good-grade SAH without intracerebral hemorrhage. Acute SIRS and serum biomarkers predict outcomes after SAH. Moreover, our study suggests the influence of surgical invasion via clipping on SIRS after SAH.