Paroxysmal generalized dystonia with clinical fluctuation affected by the menstrual cycle. (June 2020)

• Record Type: Journal Article
• Authors: Jo, Sungyang; Park, Kye Won; Choi, Nari; Ryu, Ho-Sung; Kim, KiJu; Kim, Young Jin; Chung, Sun Ju
• Is Part Of: Parkinsonism & related disorders. Volume 75(2020)
• Page Start: 48
• Page End: 49
• Publication Date: 2020-06
• Subjects: ATP1A3 -- Adolescent-onset -- Hemiplegia -- Paroxysmal dystonia -- Progesterone; Parkinson's disease -- Periodicals; Movement disorders -- Periodicals; Movement Disorders -- Periodicals; Nerve Degeneration -- Periodicals; Nervous System Diseases -- Periodicals; Parkinson Disease -- Periodicals; Tremor -- Periodicals; Parkinson, Maladie de -- Périodiques; Parkinson's disease; 616.833
• DOI: 10.1016/j.parkreldis.2020.05.009
• Languages: English
• ISSNs: 1353-8020

Abstract

Highlights: A patient with ATP1A3 mutation can present with paroxysmal generalized dystonia without hemiplegic event. Menstrual cycle could be a precipitating factor of paroxysmal movement disorder in patients with ATP1A3 mutation. Progesterone, which peaks during the mid-luteal phase might have an inhibitory effect on Na+/K+ ATPase activity.