Active microfluidic systems for cell sorting and separation. (March 2020)

• Record Type: Journal Article
• Authors: Sivaramakrishnan, Muthusaravanan; Kothandan, Ram; Govindarajan, Deenadayalan Karaiyagowder; Meganathan, Yogesan; Kandaswamy, Kumaravel
• Is Part Of: Current opinion in biomedical engineering. Volume 13(2020)
• Page Start: 60
• Page End: 68
• Publication Date: 2020-03
• Subjects: Microfluidics -- Microchannels -- Cell separation -- Cell sorting -- Clinical diagnostics; Biomedical engineering -- Periodicals; 610.28
• DOI: 10.1016/j.cobme.2019.09.014
• Languages: English
• ISSNs: 2468-4511

Abstract

Abstract: Rapid progress in the field of microfluidics coupled with increase in demand for cell separation techniques for biomedical diagnostics has gained significant attention among researchers. Designing cost-effective and miniaturized microfluidic devices with increased detection accuracy and throughput is a challenging task. Therefore, it is crucial to evaluate the current state-of-the-art microfluidic devices. This article critically reviews four different types of active microfluidic devices such as fluorescence-activated cell sorting, magnetic-activated cell sorting, dielectrophoresis, and acoustic microfluidic devices. Furthermore, their applications and limitations were discussed succinctly from an efficiency standpoint. Graphical abstract: Image 1