Plasma copeptin levels in patients with multiple sclerosis. (August 2020)

• Record Type: Journal Article
• Authors: Koseoglu, Mesrure; Ozben, Serkan; Gozubatik-Celik, Gokcen; Tutuncu, Mesude; Kucuksayan, Ertan; Hanikoğlu, Aysegul; Atakli, Dilek; Ozben, Tomris
• Is Part Of: Journal of clinical neuroscience. Volume 78(2020)
• Page Start: 143
• Page End: 146
• Publication Date: 2020-08
• Subjects: Multiple sclerosis -- Copeptin -- Antidiuretic hormone; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2020.04.095
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: Biomarkers which are sensitive and specific for disease activity for MS are highly required. Copeptin has not been investigated in MS sufficiently. First study of copeptin in the attack and after the attack in MS patients. First study of copeptin in the attack free MS. Abstract: We compared copeptin levels in relapsing-remitting multiple sclerosis (RRMS) patients with controls and investigated how plasma copeptin levels were changed with the disease period. Thirty patients with RRMS without a prior attack in the last twelve months, and 19 RRMS patients with a clinical acute attack and 30 healthy individuals were included into the study. Copeptin levels were significantly higher in all RRMS patient groups than healthy controls. Plasma copeptin levels were higher in patients in remission period compared with relapse period of 19 RRMS patients with an acute attack. We consider copeptin can be used as a potential biomarker for RRMS.