Juvenile case with the coexistence of maturity‐onset diabetes of the young 1 and later‐onset latent autoimmune diabetes in youth. Issue 4 (20th February 2020)

• Record Type: Journal Article
• Authors: Yoshida, Kei; Urakami, Tatsuhiko; Mine, Yusuke; Kuwabara, Remi; Morioka, Ichiro
• Is Part Of: Journal of diabetes investigation. Volume 11:Issue 4(2020)
• Page Start: 1010
• Page End: 1013
• Publication Date: 2020-02-20
• Subjects: β‐Cell autoimmunity -- Latent autoimmune diabetes in youth -- Maturity‐onset diabetes of the young 1; Diabetes -- Periodicals; Diabetes -- Research -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462005
• DOI: 10.1111/jdi.13215
• Languages: English
• ISSNs: 2040-1116

Abstract

Abstract: We present the case of a 12‐year‐old Japanese girl, who was positive for markers of both maturity‐onset diabetes of the young and latent autoimmune diabetes in youth. She was initially diagnosed with maturity‐onset diabetes of the young 1 based on the molecular analysis, and she later developed an autoimmune response, leading to β‐cell‐associated antibody‐positive diabetes. She was treated with incretin‐associated drugs and maintained adequate glycemic control. Pathophysiologically, there was an overlap between the two different types of diabetes, because the hyperglycemia and β‐cell stress seen in non‐autoimmune diabetes can cause β‐cell autoimmunity over time. Abstract : This paper presents the case of a 12‐year‐old Japanese girl, who was positive for markers of both, maturity‐onset diabetes of the young and latent autoimmune diabetes in youth. She was initially diagnosed with type 1 maturity‐onset diabetes of the young, and later developed an autoimmune response, leading to β‐cell‐associated antibody‐positive diabetes We believe that our study makes a significant contribution to the literature, because it suggests that it is necessary to examine the β‐cell‐associated autoantibodies over time in patients with any type of diabetes when there is a drop in endogenous insulin secretion.