Ruthenium‐Catalyzed meta‐Selective C−H Nitration of Biologically Important Aryltetrazoles. Issue 14 (3rd June 2020)

• Record Type: Journal Article
• Authors: Chen, Jian; Huang, Tianle; Gong, Xinrui; Yu, Zhu‐Jun; Shi, Yuesen; Yan, Yu‐Hang; Zheng, Yang; Liu, Xuexin; Li, Guo‐Bo; Wu, Yong
• Is Part Of: Advanced synthesis & catalysis. Volume 362:Issue 14(2020)
• Page Start: 2984
• Page End: 2989
• Publication Date: 2020-06-03
• Subjects: tetrazole -- meta-selective -- C−H nitration -- metallo-β-lactamase inhibitors.; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202000475
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: The first example of tetrazole‐directed meta ‐selective C−H nitration is described. This transformation provided a straightforward approach for the synthesis of biologically important m ‐nitroaryltetrazoles in moderate to excellent yields with good functional group compatibility. In addition, new metallo‐β‐lactamase inhibitors were obtained by further transformation of the synthesized m ‐nitroaryltetrazoles. Abstract :