Neuroprotective terpenoids from the leaves of Viburnum odoratissimum. Issue 10 (18th May 2020)

• Record Type: Journal Article
• Authors: Zhang, Yan; Zhou, Wei-Yu; Song, Xiao-Yu; Yao, Guo-Dong; Song, Shao-Jiang
• Is Part Of: Natural product research. Volume 34:Issue 10(2020)
• Page Start: 1352
• Page End: 1359
• Publication Date: 2020-05-18
• Subjects: Viburnum odoratissimum -- Terpenoids -- neuroprotective activity -- apoptosis; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1514400
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: As a part of our ongoing search for neuroprotective compounds from natural products, two new iridoid glycosides, vibsansuspenside A-B (1 -2 ), along with five known terpenoids (3 -7 ), were isolated from the dry leaves of Viburnum odoratissimum. Their chemical structures were well determined by means of NMR spectroscopic data as well as HRESIMS analysis. All compounds were detected for their neuroprotective effects against H2 O2 -induced damage in human dopaminergic neuroblastoma cells (SH-SY5Y). Among them, compound 3 displayed the most potent neuroprotective ability, and further investigation by Annexin V/PI and Western blot analysis demonstrated that compound 3 could protect SH-SY5Y cells from oxidative damage through inhibiting cell apoptosis.