Vanadium complexes with salicylaldehyde-based Schiff base ligands—structure, properties and biological activity. Issue 6 (18th March 2020)

• Record Type: Journal Article
• Authors: Szklarzewicz, Janusz; Jurowska, Anna; Hodorowicz, Maciej; Gryboś, Ryszard; Kruczała, Krzysztof; Głuch-Lutwin, Monika; Kazek, Grzegorz
• Is Part Of: Journal of coordination chemistry. Volume 73:Issue 6(2020)
• Page Start: 986
• Page End: 1008
• Publication Date: 2020-03-18
• Subjects: Vanadium -- Schiff base -- biological activity -- PTP1B -- physicochemical properties; Coordination compounds -- Periodicals; 541.2242
• DOI: 10.1080/00958972.2020.1755036
• Languages: English
• ISSNs: 0095-8972

Abstract

Abstract: Schiff base ligands based on 5-bromosalicylaldehyde and 4-tertbutylbenzhydrazide or benzhydrazide were used in syntheses of eight vanadium complexes with VOSO4 (aq), [VO(acac)2 ] and [V(acac)3 ] in ethanolic solution. In selected syntheses 1, 10-phenanthroline (phen), 2, 2'-bipyridine (bpy) or 2, 5-pyridinedicarboxylic acid (dpy) were used as co-ligands to fill the coordination sphere and to increase complex stability. The complexes were characterized by elemental analyses, IR, UV-Vis, EPR spectroscopy, cyclic voltammetry, magnetic susceptibility and for one complex two single crystal X-ray structures were determined for complexes with two different solvent molecules (H2 O and MeCN). Three complexes were found to be active in inhibition of human recombinant PTP1B, one of them is twice more active than suramin. Graphical Abstract: