A Chinese Male with Normal Hematological Indices and High Hb A2 Levels in β-Thalassemia Trait. (3rd March 2020)

• Record Type: Journal Article
• Authors: Chen, Yi-Jun; Li, You-Qiong; Liu, Qing; Tang, Lan-Yan; Lv, Fu-Tong
• Is Part Of: Hemoglobin. Volume 44:Number 2(2020)
• Page Start: 131
• Page End: 133
• Publication Date: 2020-03-03
• Subjects: β-Thalassemia (β-thal) -- Hb A2 -- normal hematological indices -- screening; Hemoglobinopathy -- Periodicals; Hemoglobin -- Periodicals; Hematology -- Periodicals; Thalassemia -- Periodicals; Blood -- Diseases -- Periodicals; 612.1111
• DOI: 10.1080/03630269.2020.1745828
• Languages: English
• ISSNs: 0363-0269

Abstract

Abstract: β-Thalassemia (β-thal) is a common hematological disorder in the Guangxi Zhuang Autonomous Region of Southern China. Heterozygous β-thal is usually associated with reduced hematological indices and increased Hb A2 levels. However, the preventive program of the regional government only conducts the screening of hematological indices [complete blood count (CBC)] especially at primary hospitals. In this study, we describe a male β-thal patient presenting normal hematological indices but with a high Hb A2 level. We proposed that hemoglobin (Hb) analysis and CBC should be performed together in the preventive screening program in regions with a high thalassemia incidence to avoid misdiagnosis.