Three new compounds from Dictamnus dasycarpus and their anti-inflammatory activities. Issue 8 (2nd August 2020)

• Record Type: Journal Article
• Authors: Gao, Peng; Wang, Ling; Zhao, Lin; Zhang, Chen; Zeng, Ke-Wu; Zhao, Ming-Bo; Zhang, Qing-Ying; Jiang, Yong; Tu, Peng-Fei; Guo, Xiao-Yu
• Is Part Of: Journal of Asian natural products research. Volume 22:Issue 8(2020)
• Page Start: 716
• Page End: 723
• Publication Date: 2020-08-02
• Subjects: Dictamnus dasycarpus -- Rutaceae -- alkaloids -- anti-inflammatory effect; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2019.1620213
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Three new compounds (1 –3 ), named dasycarine G (1 ), dasycarether (2 ), and dasycarester (3 ), along with seven known compounds (4 –10 ) obtained from the genus Dictamnus for the first time, were isolated from the root bark of Dictamnus dasycarpus . Their structures were elucidated on the basis of spectroscopic data (UV, IR, HR-ESI-MS, 1D and 2D NMR, and CD). In the in vitro assay, compounds 1, 5, 6, 9, and 10 exhibited NO inhibitory effects of LPS-induced BV-2 cells with IC50 values in the range of 10.4 μM to 27.2 μM. Graphical Abstract: