Predicting factors for disappearance of anti-mutated citrullinated vimentin antibodies in sera of patients with rheumatoid arthritis. Issue 3 (3rd May 2020)

• Record Type: Journal Article
• Authors: Ishigooka, Nozomi; Fujii, Takao; Abe, Hiroyasu; Murakami, Kosaku; Nakashima, Ran; Hashimoto, Motomu; Yoshifuji, Hajime; Tanaka, Masao; Ito, Hiromu; Ohmura, Koichiro; Morita, Satoshi; Mimori, Tsuneyo
• Is Part Of: Modern rheumatology. Volume 30:Issue 3(2020)
• Page Start: 450
• Page End: 457
• Publication Date: 2020-05-03
• Subjects: anti-citrullinated protein antibodies -- biological disease-modifying antirheumatic drug -- interstitial lung disease -- rheumatoid arthritis; Rheumatology -- Periodicals; 616.723005
• DOI: 10.1080/14397595.2019.1621439
• Languages: English
• ISSNs: 1439-7595

Abstract

Abstract: Objectives: We aimed to determine the predicting factors for disappearance of anti-mutated citrullinated vimentin antibody (anti-MCV Ab) in sera from rheumatoid arthritis (RA) patients. Methods: In 2013, 95 RA patients whose Disease Activity Score with erythrocyte sedimentation rate were moderate to severe (DAS28-ESR ≥3.2) at baseline were enrolled. Titers of anti-MCV Ab and anti-cyclic citrullinated peptide (anti-CCP) Ab for 2013 and 2014 were measured. The association of anti-MCV disappearance with disease activity, treatment, interstitial lung disease (ILD), and serum markers of ILD were retrospectively examined. Predicting factors of anti-MCV disappearance were determined by multivariable analysis. Results: While anti-CCP positivity rate did not change during the year, anti-MCV Ab changed from positive to negative in 18 patients (=19.0%). Continuous biological disease-modifying anti-rheumatic drug use, prednisolone dose (≥5.0 mg daily), and low KL-6 level (<191 U/mL) were determined as predicting factors of anti-MCV disappearance by multivariable analysis. In our cohort, anti-MCV Ab disappearance was not linked to clinical and radiological improvement. Conclusion: Different from anti-CCP Ab, anti-MCV Ab in sera from RA patients can disappear in a year. Some predicting factors for such negative seroconversion were found, whereas clinical significance of anti-MCV Ab disappearance was undetermined.