Safety and efficacy of tranexamic acid in spinal canal tumors: a retrospective cohort study. (3rd May 2020)

• Record Type: Journal Article
• Authors: Zhang, Heng Zhu; Dong, Lun; Wang, Huan Ming; Hu, Fei; Shao, Qiang; Chen, Xu; Chen, Lang
• Is Part Of: British journal of neurosurgery. Volume 34:Number 3(2020)
• Page Start: 313
• Page End: 315
• Publication Date: 2020-05-03
• Subjects: Spinal canal tumor -- tranexamic acid -- intraoperative bleeding; Nervous system -- Surgery -- Periodicals; 617.48
• DOI: 10.1080/02688697.2020.1717442
• Languages: English
• ISSNs: 0268-8697

Abstract

Abstract: Objective: The use of tranexamic acid (TXA) has become popular in spinal surgery, the purpose of this study is to investigate the effectiveness and safety of intraoperative TXA used to reduce surgical bleeding and transfusion requirements in spinal canal tumor resection. Methods: The data for patients with spinal canal tumors treated in our hospital from June 2014 to June 2017 were collected. The patients (≥18 years of age) were divided into a TXA group (group A, n = 30) and a non-TXA group (group B, n = 30). The TXA dose regimen in group A comprised a loading dose of 10 mg/kg 30 minutes before the operation, followed by a maintenance dose of 1 mg/kg per hour during the operation. Group B was not given TXA. The operation time, intraoperative blood loss, postoperative drainage, postoperative complications, coagulation function such as plasma thrombin time(PT), prothrombin time(TT), activated thromboplastin time(APTT), fibrinogen (Fib) were statistically analyzed. Results: The intraoperative blood loss and postoperative drainage volume were significant lower in group A than in group B ( p <.05). There were no significant differences in the operation time, plasma thrombin time, prothrombin time, activated thromboplastin time, or fibrinogen between the two groups before and after the operation ( p >.05), and no thrombotic complications occurred. Conclusion: TXA used during spinal tumor surgery can reduce the amount of intraoperative blood loss and postoperative drainage without increasing the risk of deep vein thrombosis and related complications.