Factors associated with MRI detection of occult lesions in newly diagnosed breast cancers. Issue 4 (26th January 2020)

• Record Type: Journal Article
• Authors: Wecsler, Julie; Jeong, Young Ju; Raghavendra, Akshara S.; Mack, Wendy J.; Tripathy, Debasish; Yamashita, Mary W.; Sheth, Pulin A.; Hovanessian Larsen, Linda; Russell, Christy A.; MacDonald, Heather; Sener, Stephen F.; Lang, Julie E.
• Is Part Of: Journal of surgical oncology. Volume 121:Issue 4(2020)
• Page Start: 589
• Page End: 598
• Publication Date: 2020-01-26
• Subjects: contralateral cancer -- multicentricity -- multifocality; Cancer -- Surgery -- Periodicals; Neoplasms -- Periodicals; 616
• DOI: 10.1002/jso.25855
• Languages: English
• ISSNs: 0022-4790

Abstract

Abstract: Background: The use of preoperative magnetic resonance imaging (MRI) for newly diagnosed breast cancer remains controversial. We examined factors associated with detection of occult multicentric, multifocal, and contralateral malignant lesions only seen by MRI. Methods: We performed a retrospective analysis of consecutive patients undergoing preoperative MRI for breast cancer. Clinicopathologic data were assessed regarding the findings of multifocality, multicentricity, and the presence of contralateral lesions. We analyzed the association of factors with these findings on MRI. Results: Of 857 patients undergoing MRI, 770 patients met inclusion criteria. Mean age was 54.7 years. Biopsy‐proven detection rates by MRI for multifocal, multicentric, and contralateral cancers were 6.2% (48 of 770), 1.9% (15 of 770) and 3.1% (24 of 770), respectively. African American race and heterogeneously or extremely dense mammographic density were associated with multifocal cancers on MRI. Larger lesion size and mammographic density were associated with multicentric cancers. Invasive lobular carcinoma (ILC) and progesterone receptor (PR)‐positivity were associated with contralateral cancers. Conclusions: African American race, heterogeneously or extremely dense mammographic density, ILC, and PR‐positivity were associated with additional biopsy‐proven cancers based on MRI. These factors should be considered when assessing the clinical utility of preoperative breast MRI.