Ferroptosis resistance mediated by exosomal release of iron. (3rd May 2020)

• Record Type: Journal Article
• Authors: Brown, Caitlin W.; Mercurio, Arthur M.
• Is Part Of: Molecular & cellular oncology. Volume 7:Number 3(2020)
• Publication Date: 2020-05-03
• Subjects: Ferroptosis -- PROMININ2 -- iron -- multivesicular body -- exosome -- breast cancer -- therapy -- GPX4; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2020.1730144
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: Understanding how cells resist ferroptosis is necessary for exploiting this iron-dependent mode of cell death for the treatment of cancer and other diseases. We discovered that cells resist ferroptosis by enabling a PROMININ2-dependent iron export pathway involving multivesicular body/exosome trafficking of iron out of the cell, diminishing the intracellular iron needed for ferroptosis.