A new Cu(II)-based metal-organic framework constructed from the terpyridine tetrazolate ligand: structural characterization and anticancer activity on nasopharyngeal carcinoma. Issue 9 (1st September 2020)

• Record Type: Journal Article
• Authors: Gu, Jing-Ping; Yuan, Feng; Xiang, Yi
• Is Part Of: Inorganic and nano-metal chemistry. Volume 50:Issue 9(2020)
• Page Start: 801
• Page End: 807
• Publication Date: 2020-09-01
• Subjects: Metal-organic framework -- terpyridine tetrazolate ligand -- anti-cancer activity; Inorganic compounds -- Synthesis -- Periodicals; Nanostructured materials -- Periodicals; Reactivity (Chemistry) -- Periodicals; Inorganic compounds -- Synthesis; Nanostructured materials; Reactivity (Chemistry); Periodicals; 546
• DOI: 10.1080/24701556.2020.1725049
• Languages: English
• ISSNs: 2470-1556

Abstract

Abstract: In the current study, a new Cu(II)-based metal-organic framework (MOF) formulated as {[Cu3 (L)6 (H2 O)]·(H2 O)4 }n (1 ) (L = 4-(tetrazol-5-yl)phenyl-4, 2′:6′, 4″-terpyridine), has been synthesized by a solvothermal method and structurally characterized via the single crystal X-ray diffraction, elemental analysis, powder X-ray diffraction along with the thermogravimetric analysis. After the synthesis of the compound 1, its inhibitory effect on the viability of CNE-1 nasopharyngeal cancer cells were detected. Firstly, the Cell Counting Kit-8 (CCK-8) was performed to determine the anti-cancer activity of compound 1 in vitro, as well as the half maximal inhibitory concentration (IC50 ) value of compound 1 . In addition to this, Annexin V-FITC/PI assay was conducted the apoptosis of CNE-1 cells after compound 1 treatment. The H2DCF-DA assay was carried out to measure the ROS accumulation in CNE-1 cells after compound 1 treatment.