Mouse models of hemostasis. (18th May 2020)

• Record Type: Journal Article
• Authors: Mohammed, Bassem M.; Monroe, Dougald M.; Gailani, David
• Is Part Of: Platelets. Volume 31:Number 4(2020)
• Page Start: 417
• Page End: 422
• Publication Date: 2020-05-18
• Subjects: Bleeding -- hemostasis -- mouse models; Blood platelets -- Periodicals; Blood Platelets -- Periodicals; 615.39
• DOI: 10.1080/09537104.2020.1719056
• Languages: English
• ISSNs: 0953-7104

Abstract

Abstract: Hemostasis is the normal process that produces a blood clot at a site of vascular injury. Mice are widely used to study hemostasis and abnormalities of blood coagulation because their hemostatic system is similar in most respects to that of humans, and their genomes can be easily manipulated to create models of inherited human coagulation disorders. Two of the most widely used techniques for assessing hemostasis in mice are the tail bleeding time (TBT) and saphenous vein bleeding (SVB) models. Here we discuss the use of these methods in the evaluation of hemostasis, and the advantages and limits of using mice as surrogates for studying hemostasis in humans.