Molecular spectroscopic behaviors of beta-arbutin in anti-skin cancer. Issue 3 (15th March 2020)

• Record Type: Journal Article
• Authors: Su, Yanbin; Sun, Xuwei; Wu, Ruixue; Zhang, Xing; Tu, Yunzhou
• Is Part Of: Spectroscopy letters. Volume 53:Issue 3(2020)
• Page Start: 172
• Page End: 183
• Publication Date: 2020-03-15
• Subjects: Anti-skin cancer -- beta-arbutin -- mitochondrion -- molecular spectroscopic behavior -- trans-crotonaldehyde; Spectrum analysis -- Periodicals; 543.5
• DOI: 10.1080/00387010.2020.1715441
• Languages: English
• ISSNs: 0038-7010

Abstract

Abstract: The purpose of this study was to explore the molecular spectroscopic behaviors of the beta-arbutin on the toxic aldehyde of trans-crotonaldehyde in anti-skin cancer. Results revealed that both hydroxymethyl and phenolic hydroxyl of beta-arbutin led to the shift of the maximum ultraviolet peak of trans-crotonaldehyde from a very significant absorption peak at 300 nm to a very weak absorption peak at 310 nm and the significant shift of the aldehyde Raman band at 1689/cm of the toxic trans-crotonaldehyde in mitochondria and aldehyde dehydrogenase, respectively. The beta-arbutin acting on the toxic trans-crotonaldehyde highlighted the potential of anti-skin cancer and provided a valuable clue for the new application of the beta-arbutin.