Carotid arterial input function as an inverse problem in kinetic modeling of [18F]2-fluoro-2 deoxy-D-glucose(FDG). Issue 3 (3rd May 2020)

• Record Type: Journal Article
• Authors: Hauser, Eliete B.; Venturin, Gianina T.; Greggio, Samuel; Borelli, Wyllians V.; DaCosta, Jaderson
• Is Part Of: Computer methods in biomechanics and biomedical engineering. Volume 8:Issue 3(2020)
• Page Start: 273
• Page End: 276
• Publication Date: 2020-05-03
• Subjects: Laplace transform -- positron emission tomography (PET) -- kinetic modelling -- image-derived input function -- convolution integral -- nonlinear regression; Imaging systems in biology -- Periodicals; Imaging systems in medicine -- Periodicals; Biomechanics -- Data processing -- Periodicals; Biomedical engineering -- Periodicals; 616.0757
• DOI: 10.1080/21681163.2019.1647460
• Languages: English
• ISSNs: 2168-1163

Abstract

ABSTRACT: A two-tissue reversible compartment model is solved by Laplace transform method for kinetic modelling of [18F]2-fluoro-2deoxy-D-glucose, in order to quantify amyloid in positron emission tomography image. A reverse engineer technic is applied to determine the input function (Ca(t)) that represents the time course of tracer concentration arterial blood. Ca(t) is obtained by nonlinear regression and non-invasively from the time–activity curve in a carotid volume of interest. After calculating a convolution integral, the analytical solution is completely described.