Prevalence of functional dyspepsia-like symptoms in ulcerative colitis patients in clinical remission and overlap with irritable bowel syndrome-like symptoms. (3rd May 2020)

• Record Type: Journal Article
• Authors: Kotani, Satoshi; Fukuba, Nobuhiko; Kawashima, Kousaku; Mishima, Yoshiyuki; Sonoyama, Hiroki; Okimoto, Eiko; Tada, Yasumasa; Oka, Akihiko; Tamagawa, Yuji; Oshima, Naoki; Mishiro, Tsuyoshi; Tobita, Hiroshi; Shibagaki, Kotaro; Moriyama, Ichiro; Ishimura, Norihisa; Kushiyama, Yoshinori; Fujishiro, Hirofumi; Ishihara, Shunji
• Is Part Of: Scandinavian journal of gastroenterology. Volume 55:Number 5(2020)
• Page Start: 560
• Page End: 564
• Publication Date: 2020-05-03
• Subjects: Inflammatory bowel disease -- ulcerative colitis -- functional dyspepsia-like symptoms -- irritable bowel syndrome-like symptoms -- clinical remission; Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; 616.33
• DOI: 10.1080/00365521.2020.1761998
• Languages: English
• ISSNs: 0036-5521

Abstract

Abstract: Objective: Quiescent ulcerative colitis (UC) patients often have irritable bowel syndrome (IBS)-like symptoms and we recently showed that the prevalence of IBS-like symptoms in UC patients in clinical remission was significantly higher as compared to healthy control subjects. However, the prevalence of functional dyspepsia (FD)-like symptoms in quiescent UC patients remains unknown. The purpose of this study was to evaluate the prevalence of FD-like symptoms and the overlap with IBS-like symptoms in such patients. Materials and Methods: We reanalyzed the records of UC patients in remission using the subject cohort from our previous study. Clinical remission was defined as a clinical activity index (CAI) value ≤4 for at least 6 months. Diagnoses of FD- and IBS-like symptoms were evaluated by questionnaire according to the Rome III criteria. Results: One hundred seventy-two UC patients in clinical remission and 330 healthy control subjects were analyzed. Of the 172 patients, 9 (5.2%) met the criteria of FD, which was comparable with the controls (22/330, 6.7%). The prevalence rate of FD-like symptoms in UC patients with IBS-like symptoms (7/46, 15.2%) was lower as compared to that of the control subjects (6/16, 37.5%). On the other hand, a high percentage of the UC patients with FD-like symptoms also had IBS-like symptoms (7/9, 77.8%). Conclusions: Although the prevalence of FD-like symptoms in quiescent UC patients with IBS-like symptoms was low, UC patients with FD-like symptoms frequently had IBS-like symptoms.