Applications and perspective of silicon particles in hyperpolarized 29Si magnetic resonance imaging. Issue 6 (2nd July 2020)

• Record Type: Journal Article
• Authors: Luu, Quy Son; Kim, Jiwon; Jo, Donghyeok; Jeong, Jihye; Lee, Youngbok
• Is Part Of: Applied spectroscopy reviews. Volume 55:Issue 6(2020)
• Page Start: 476
• Page End: 490
• Publication Date: 2020-07-02
• Subjects: Hyperpolarization -- silicon particles -- 29Si magnetic resonance imaging -- cancer diagnosis; Spectrum analysis -- Periodicals; 535.84
• DOI: 10.1080/05704928.2019.1676255
• Languages: English
• ISSNs: 0570-4928

Abstract

Abstract: Silicon particles in combination with the dynamic nuclear polarization (DNP) method have recently attracted attention as promising biomedical platforms for drug delivery and medical diagnostics in magnetic resonance spectroscopy (MRS) and MR imaging (MRI). In the present review, silicon particles were investigated as potential diagnostic probes for 29 Si MRI to research in vivo and in vitro diverse bimolecular processes. Hyperpolarization characteristics of silicon particles based on their size, morphology, and physicochemical properties, were broadly demonstrated. Moreover, in vivo applications with the hyperpolarized silicon materials indicate the potential of the new diagnostic platform and will be of significant value for early diagnosis of diseases, including cancer.