Recent advances in potential targets for eosinophilic esophagitis treatments. (2nd April 2020)

• Record Type: Journal Article
• Authors: Oliva, Salvatore; Azouz, Nurit P.; Stronati, Laura; Rothenberg, Marc E.
• Is Part Of: Expert review of clinical immunology. Volume 16:Number 4(2020)
• Page Start: 421
• Page End: 428
• Publication Date: 2020-04-02
• Subjects: Eosinophilic esophagitis -- proteases -- fibrosis -- biologics -- treatment -- biologics; Clinical immunology -- Periodicals; 616.079
• DOI: 10.1080/1744666X.2020.1742110
• Languages: English
• ISSNs: 1744-666X

Abstract

ABSTRACT: Introduction : Diagnostic and therapeutic strategies in eosinophilic esophagitis (EoE) are constantly evolving. Recently, the improved understanding of EoE pathogenesis has led to identification of a variety of other potential targets that have never been considered before. Areas covered : In September 2019, we performed structured literature searches in Medline and PubMed, Cochrane meta-analyses, and abstracts of international congresses to review new potential therapeutic approaches for EoE. Expert opinion : The advent of omics disciplines has been helping in finding new molecular targets in EoE pathogenesis and may provide future guidance for deep phenotyping of the disease and therefore facilitate the possibility of personalized medicine. Interestingly, these new treatments should be focused on the restoration of epithelial barrier dysfunction, downregulation of specific molecular pathways of eosinophilic inflammation, and finally, prevention of esophageal remodeling. In this review, we highlight the most recent insights in EoE pathogenesis, which open new pathways for developing new therapeutic targets for clinical practice.