Improving quick and accurate diagnosis of childhood JIA-uveitis from a pediatric rheumatology perspective. (3rd March 2020)

• Record Type: Journal Article
• Authors: Rodriguez-Smith, Jackeline; Yeh, Steven; Angeles-Han, Sheila T.
• Is Part Of: Expert review of ophthalmology. Volume 15:Number 2(2020)
• Page Start: 101
• Page End: 109
• Publication Date: 2020-03-03
• Subjects: Biomarkers -- childhood uveitis -- juvenile idiopathic arthritis -- uveitis -- noninfectious uveitis -- pediatric uveitis -- risk factors -- tears; Ophthalmology -- Periodicals; 617.7005
• DOI: 10.1080/17469899.2020.1739521
• Languages: English
• ISSNs: 1746-9899

Abstract

ABSTRACT: Introduction : Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatic disease associated with uveitis. JIA-associated uveitis (JIA-U) is typically asymptomatic, chronic, and can lead to sight-threatening complications. This review will provide approaches to improve the diagnosis and outcomes of children with JIA-U. Areas covered : We will provide updates on risk factors for uveitis onset and ocular complications, improvements in the ophthalmic screening schedule for uveitis detection, and potential strategies to advance the diagnosis and monitoring of JIA-U using advanced ophthalmic imaging and diagnostic equipment and laboratory biomarkers. Expert opinion : There is a lack of high-quality research in JIA-U and few randomized controlled trials, underscoring the urgent need for further studies in this population. Early uveitis diagnosis combined with timely and appropriate treatment can improve visual outcomes. Improved knowledge of uveitis pathogenesis, risk factors for uveitis onset, measurement of uveitis outcomes, and optimal treatment are crucial.