MRI monitoring of small and medium-sized vestibular schwannomas: predictors of growth. (3rd May 2020)

• Record Type: Journal Article
• Authors: Fieux, Maxime; Pouzet, Claudine; Bonjour, Maxime; Zaouche, Sandra; Jouanneau, Emmanuel; Tringali, Stéphane
• Is Part Of: Acta oto-laryngologica. Volume 140:Number 5(2020)
• Page Start: 361
• Page End: 365
• Publication Date: 2020-05-03
• Subjects: Acoustic neuroma -- vestibular schwannoma -- growth -- MRI monitoring -- risk factor; Otolaryngology -- Periodicals; Ear -- Diseases -- Periodicals; Throat -- Diseases -- Periodicals; Otolaryngology -- Electronic Resources; Otorhinolaryngologic Diseases; 617.8
• DOI: 10.1080/00016489.2020.1717608
• Languages: English
• ISSNs: 0001-6489

Abstract

Abstract: Background: Vestibular schwannomas are among the most common intracranial tumours. Their growth is difficult to predict. Objectives: To study the evolution of small and medium-sized vestibular schwannomas (VSs) and identify factors predictive of growth. Material and methods: This was a retrospective longitudinal study at a tertiary referral centre from January 2011 to January 2018. The inclusion criteria were radiological diagnosis of sporadic unilateral VS of stage I or II. Radiological and clinical data were analysed descriptively and by multivariate logistic regression to identify factors predictive of growth. Results: A total of 1105 cases were discussed in multidisciplinary meetings and 336 patients were included with a mean age of 57.8 years and a mean follow-up time of 24 months. Around two thirds of these patients (62.8%) had non-progressive tumours. Factors identified as predictive of VS growth were the size at diagnosis (OR = 2.622, 95% CI, 1.50–4.66; p = .001) and internal auditory canal filling (OR = 7.672; 95% CI, 4.52–13.43; p < .001). Conclusions and significance: Monitoring is the primary treatment modality for small or medium-sized VSs. As reported here for the first time, internal auditory canal filling is significantly associated with VS growth.