Bistachybotrysin K, one new phenylspirodrimane dimer from Stachybotrys chartarum with potent cytotoxic activity. Issue 5 (3rd May 2020)

• Record Type: Journal Article
• Authors: Jia, Xiao-Na; Zhao, Jin-Lian; Feng, Jia-Min; Chen, Ri-Dao; Xie, Ke-Bo; Chen, Da-Wei; Li, Yan; Liu, Ji-Mei; Dai, Jun-Gui
• Is Part Of: Journal of Asian natural products research. Volume 22:Issue 5(2020)
• Page Start: 496
• Page End: 502
• Publication Date: 2020-05-03
• Subjects: Bistachybotrysin -- phenylspirodrimane dimer -- Stachybotrys chartarum -- cytotoxicity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2019.1680645
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Bistachybotrysin K (1 ), one new phenylspirodrimane dimer with a central 6/7 oxygen heterocycle core, was isolated from the fungus Stachybotrys chartarum CGMCC 3.5365. Its structure was elucidated by extensive spectroscopic data and single-crystal X-ray diffraction. Compound 1 showed significant cytotoxicity against human tumor cell lines HCT116, NCI-H460, BGC823, Daoy, and HepG2 with IC50 values in the range of 1.1–4.7 µM. Graphical Abstract: