Cost-effectiveness of mirogabalin for the treatment of post-herpetic neuralgia in Taiwan. (3rd May 2020)

• Record Type: Journal Article
• Authors: Ye, Xin; Gray, Emma; Wang, Yen-Feng; Wang, Shuu-Jiun
• Is Part Of: Journal of medical economics. Volume 23:Number 5(2020)
• Page Start: 529
• Page End: 536
• Publication Date: 2020-05-03
• Subjects: Cost-effectiveness -- mirogabalin -- post-herpetic -- neuralgia -- Taiwan; C52 -- N35; Medical care -- Cost control -- Periodicals; Medical economics -- Periodicals; 362.10941
• DOI: 10.1080/13696998.2020.1720694
• Languages: English
• ISSNs: 1369-6998

Abstract

Abstract: Objectives: To assess the cost-effectiveness of mirogabalin versus no treatment or pregabalin in patients with post-herpetic neuralgia (PHN) from a third-party perspective in Taiwan. Methods: A Markov model, which was developed with 2-week cycles and 1-year time horizon from the Taiwanese National Health Insurance Administration perspective, consisted of three health states: "mild, " "moderate, " and "severe" pain. Average daily pain score (ADPS) was assessed at the end of each cycle. Patients either remained in, or transitioned from, their assigned health state to a different state according to their pain score changes. All patients entered the model in "moderate" (4 ≤ ADPS <7) or "severe" (7 ≤ ADPS ≤ 10) pain health states. Efficacy data was informed by the pivotal Phase III trial, or by a network meta-analysis (NMA). Utility values were obtained from published literature and cost data from Taiwanese clinical experts and the Taiwan National Health Insurance Administration, using 2018 New Taiwan dollar (NT$). Probabilistic analysis was conducted to test the robustness of base case results. Results: Head-to-head analysis showed mirogabalin 30 mg to be cost-effective versus placebo in PHN. The deterministic analysis estimated a quality-adjusted life years gain of 0.041 at an ICER of NT$11, 231 (US$365) versus no treatment (ICER: NT$274, 567 [US$8, 900]). In the NMAs, mirogabalin was cost-effective compared to pregabalin 150 mg (ICER: NT$515, 881 [US$16, 720]) and 300 mg (ICER: NT$201, 671 [US$6, 535]). Mirogabalin 30 mg dominated pregabalin 600 mg. Results from sensitivity and scenario analyses confirmed these results. Conclusion: Mirogabalin 30 mg, a potent and selective α2δ ligand, is a cost-effective treatment option for PHN in Taiwan, with ICERs below the willingness-to-pay threshold.