The role of mouse models in colorectal cancer research—The need and the importance of the orthotopic models. Issue 1 (11th March 2020)

• Record Type: Journal Article
• Authors: Oliveira, Rui C.; Abrantes, Ana Margarida; Tralhão, José Guilherme; Botelho, Maria Filomena
• Is Part Of: Animal models and experimental medicine. Volume 3:Issue 1(2020)
• Page Start: 1
• Page End: 8
• Publication Date: 2020-03-11
• Subjects: colorectal cancer -- mouse model -- orthotopic model; Laboratory animals -- Periodicals; Diseases -- Animal models -- Periodicals; Animal models in research -- Periodicals; Veterinary medicine -- Periodicals; Laboratory Animal Science; Disease Models, Animal; Animals, Laboratory; Animal Welfare; Veterinary Medicine; Animal models in research; Diseases -- Animal models; Laboratory animals; Veterinary medicine; Periodicals; Fulltext; Internet Resources; Periodicals; Periodicals; 616.0273
• DOI: 10.1002/ame2.12102
• Languages: English
• ISSNs: 2576-2095

Abstract

Abstract: Colorectal cancer is a worldwide health burden, with high incidence and mortality, especially in the advanced stages of the disease. Preclinical models are very important and valuable to discover and validate early and specific biomarkers as well as new therapeutic targets. In order to accomplish that, the animal models must replicate the clinical evolution of the disease in all of its phases. In this article, we review the existent mouse models, with their strengths and weaknesses in the replication of human cancer disease progression, with major focus on orthotopic models.