Phytochemical, antimicrobial and antiquorum-sensing studies of pulicaria undulata L.: a revision on the structure of 1β, 2α, 3β, 19α, 23-pentahydroxy-urs-12-en-28-oic acid. Issue 6 (18th March 2020)

• Record Type: Journal Article
• Authors: Abdel Bar, Fatma M.; Elsbaey, Marwa; Taha, Noha; Elgaml, Abdelaziz; Abdel-Fattah, Gamal M.
• Is Part Of: Natural product research. Volume 34:Issue 6(2020)
• Page Start: 804
• Page End: 809
• Publication Date: 2020-03-18
• Subjects: Pulicaria undulata -- Asteraceae -- Pentahydroxy triterpenoid -- Pentahydroxy ursolic acid -- 1β, 2α, 3β, 19α-pentahydroxy-urs-12-en-28-oic acid -- Antimicrobial -- Antiquorum-sensing; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1503658
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Phytochemical study of the aerial part of Pulicaria undulata L. led to the isolation of nine compounds. The structure of 1β, 2α, 3β, 19α, 23-pentahydroxy-urs-12-en-28-oic acid (4 ) was revised and confirmation of the stereochemical configuration of the hydroxyl groups was established using NOESY and selective decoupling experiments. The other compounds were identified as 1, 2-dehydro-1, 10α-dihydropseudoivalin (1 ), axillarin (2 ), grandifloric acid-15-β-glucoside (3 ), myrianthic acid (5 ), caffeic acid (6 ), quercetin (7 ), paniculoside IV (8 ) and caffeic anhydride (9 ). The structures were characterized by 1 D, 2 D NMR spectroscopy and confirmed with HRMS. Antimicrobial and antiquorum-sensing activities of the different extracts and isolated compounds of the plant were investigated. Generally, the phenolic rather than the terpenoidal compounds exhibited remarkable antimicrobial and antiquorum-sensing activity.