A high-toughness and high cell adhesion polyvinyl alcohol（PVA-hyaluronic acid (HA)-human-like collagen (HLC) composite hydrogel for cartilage repair. Issue 14 (21st September 2020)

• Record Type: Journal Article
• Authors: Xie, Jiaheng; Fan, Daidi
• Is Part Of: International journal of polymeric materials. Volume 69:Issue 14(2020)
• Page Start: 928
• Page End: 937
• Publication Date: 2020-09-21
• Subjects: Cartilage repair scaffold -- cell adhesion -- human-like collagen -- hyaluronic acid -- polyvinyl acetate hydrogel; Polymers -- Periodicals; Plastics -- Periodicals; 620.19205
• DOI: 10.1080/00914037.2019.1631824
• Languages: English
• ISSNs: 0091-4037

Abstract

Abstract: Polyvinyl alcohol (PVA) has good mechanical stability and flexibility. However, PVA hydrogels of low compressive strength and low cell adhesion is still considered difficult to apply to tissue engineering cartilage. In this paper, we prepared PVA-HA-HLC hydrogel by freeze-thaw method. The results showed that the hydrogel had an average pore diameter of 100–300 μm, a porosity of 94.52%, a maximum compressive strain of 90%, and a compressive strength of 5.56 MPa. Animal cartilage defect test results showed that PVA-HA-HLC hydrogel repaired cartilage defects. In short, PVA-HA-HLC hydrogels could be used as cartilage repair scaffold. GRAPHICAL ABSTRACT: