Two new xanthones, a new lignin, and twenty phenolic compounds from Smilax china and their NO production inhibitory activities. Issue 6 (2nd June 2020)

• Record Type: Journal Article
• Authors: Zheng, Xiang-Wei; Zhang, Lei; Zhang, Wei-Yue; Zhang, Yan; Wang, Jian-Ying; Liu, Bao-Cheng; Hu, Xiao-Juan; Hong, Yan-Long; Yang, Yong-Qing
• Is Part Of: Journal of Asian natural products research. Volume 22:Issue 6(2020)
• Page Start: 509
• Page End: 520
• Publication Date: 2020-06-02
• Subjects: Smilax china L. -- xyxanthone -- lignin -- phenoloid -- NO production inhibitory activity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2019.1598395
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Two new xanthones smilone A (1 ), smilone B (2 ), and a new lignin smilgnin A (3 ) were isolated from the rhizomes of Smilax china L., together with three known xanthones (4 –6 ), four lignins (7 –10 ), two flavones (11, 12 ), two stilbenoids (13, 14 ), and ten organic phenoloids (15–24 ). Of them, compounds 4–6 were isolated from the genus Smilax for the first time. The structures of 1–24 were elucidated by the extensive analysis of spectral data and compared with the literature. All compounds were evaluated for their inhibitory effects against LPS-induced NO production in RAW264.7 macrophages. Among them, compound 24 exhibited significant inhibitory activity against NO production (IC50 = 1.26 µM), while compounds 3, 6, and 7 showed weak activities at the concentration of 50 μM.