Changes in cortical protein markers of iron transport with gender, major depressive disorder and suicide. (7th February 2020)

• Record Type: Journal Article
• Authors: Dean, Brian; Tsatsanis, Andrew; Lam, Linh Q.; Scarr, Elizabeth; Duce, James A.
• Is Part Of: World journal of biological psychiatry. Volume 21:Number 2(2020)
• Page Start: 119
• Page End: 126
• Publication Date: 2020-02-07
• Subjects: Iron regulatory proteins -- cortex -- bipolar disorder -- major depressive disorder -- prion protein; Biological psychiatry -- Periodicals; Biological Psychiatry -- Periodicals; 616.89
• DOI: 10.1080/15622975.2018.1555377
• Languages: English
• ISSNs: 1562-2975

Abstract

Abstract: Objectives : The objective of this study was to determine whether a breakdown in proteins regulating cortical iron homeostasis could be involved in the pathophysiology of mood disorders. Methods : Levels of select proteins responsible for cortical iron transport were quantitated by Western blotting of Brodmann's (BA) areas 6 and 10 from patients with major depressive disorder ( n = 13), bipolar disorder ( n = 12) and age/sex matched controls ( n = 13). Results : We found the inactive form of ceruloplasmin was lower in BA 6 from males compared to females. Levels of copper containing ceruloplasmin was lower in BA 6 from suicide completers whilst levels of amyloid precursor protein, TAU and transferrin were higher in BA 10 from those individuals. The level of prion protein was lower in BA 6 from subjects with major depressive disorder. Conclusions : Our data suggests that perturbation in cortical iron transport proteins is not prevalent in mood disorders. By contrast, our data suggests changes in iron transport proteins in BA 6 and BA 10 are present after suicide completion. If these changes were present before death, they could have had a role in the genesis of the contemplation and completion of suicide.