Theoretical basis of optimal therapy for individual patients in chronic myeloid leukemia : A mathematical approach. Issue 3 (2nd April 2020)

• Record Type: Journal Article
• Authors: Parajdi, Lorand Gabriel; Precup, Radu; Dima, Delia; Moisoiu, Vlad; Tomuleasa, Ciprian
• Is Part Of: Journal of interdisciplinary mathematics. Volume 23:Issue 3(2020)
• Page Start: 669
• Page End: 690
• Publication Date: 2020-04-02
• Subjects: 92B05 -- 92D25 -- 92C50; Mathematical model -- Chronic myeloid leukemia -- Dynamic system -- Optimization problem; Mathematics -- Periodicals; Mathematics; Periodicals; 510.5
• DOI: 10.1080/09720502.2019.1681699
• Languages: English
• ISSNs: 0972-0502

Abstract

Abstract: Even if the successful pharmacological therapy for chronic myeloid leukemia has reached today a near normal life expectancy in a patient diagnosed with this malignancy, almost one in four patients will change the line of tyrosin-kinase inhibitors during therapy, may it be due to poor response of due to intolerance to therapy. In this paper, starting from a mathematical characterization of the chronic phase in myeloid leukemia, a theoretical investigation of optimal therapy is undertaken as base for further pharmaceutical research and personalized treatment protocols.