Steroidal glycosides from the bulbs of Lilium speciosum. (June 2020)

• Record Type: Journal Article
• Authors: Iguchi, Tomoki; Yokosuka, Akihito; Kuroda, Minpei; Takeya, Mayuko; Hagiya, Mizuki; Mimaki, Yoshihiro
• Is Part Of: Phytochemistry letters. Volume 37(2020)
• Page Start: 21
• Page End: 28
• Publication Date: 2020-06
• Subjects: Lilium speciosum -- Liliaceae -- Bulb -- Spirostanol glycoside -- Cholestane glycoside -- Cytotoxic activity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2020.01.008
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Eight new spirostanol glycosides and a new cholestane glycoside were isolated from the bulbs of Lilium speciosum . The isolated compounds and the aglycones were evaluated for their cytotoxic activity against HL-60 and A549 cells. Compounds 12, 20, and 21 exhibited moderate cytotoxic activity. Abstract: Steroidal glycosides (1 -21 ), including eight new spirostanol glycosides (1 -8 ) and a new cholestane glycoside (9 ), were isolated from the bulbs of Lilium speciosum . The structures of the new compounds were determined based on spectroscopic data analysis and hydrolytic cleavage reactions. The isolated compounds and their aglycones (1a, 8a, and 9a ) were evaluated for their cytotoxicity against HL-60 human acute promyelocytic leukemia cells and A549 human lung carcinoma cells. Compounds 12 and 21 exhibited moderate cytotoxic activity toward HL-60 and A549 cells, with IC50 values of 6.9 μM and 5.1 μM against HL-60 cells, and 7.6 μM and 4.4 μM against A549 cells, respectively. Compound 20 only showed moderate cytotoxicity toward A549 cells, with an IC50 value of 6.7 μM.