Effect of TRF1 rs3863242 polymorphism on telomere length in omethoate-exposed workers. Issue 6 (2nd June 2020)

• Record Type: Journal Article
• Authors: Zhou, Xiaoshan; Wei, Wan; Duan, Xiaoran; Zhang, Hui; Feng, Xiaolei; Wang, Tuanwei; Wang, Pengpeng; Ding, Mingcui; Liu, Suxiang; Li, Lei; Yao, Wu; Wang, Qi; Acquaye, Reuben Mensah; Liang, Haiyong; Wang, Wei; Yang, Yongli
• Is Part Of: Journal of environmental science and health. Volume 55:Issue 6(2020)
• Page Start: 525
• Page End: 529
• Publication Date: 2020-06-02
• Subjects: Omethoate -- telomere length -- polymorphism -- telomere-binding protein genes -- TRF1 rs3863242; Pesticides -- Environmental aspects -- Periodicals; Food contamination -- Periodicals; Agricultural wastes -- Environmental aspects -- Periodicals; Ecology -- periodicals; Pesticides -- toxicity -- periodicals; Food Contamination -- periodicals; 363.73
• DOI: 10.1080/03601234.2020.1728167
• Languages: English
• ISSNs: 0360-1234

Abstract

Abstract: Telomere length was found to be associated with omethoate exposure and polymorphisms in certain genes among occupational workers. However, whether the polymorphisms in telomere-binding protein genes influence telomere length remains unclear. To explore the correlation between telomere length and polymorphisms in telomere-binding protein genes, telomere length in peripheral blood leukocytes was determined by real-time quantitative polymerase chain reaction in 180 omethoate-exposed workers and 115 healthy controls. Polymorphisms in 10 pairs of alleles were detected using flight mass spectrometry or polymerase chain reaction–restriction fragment length polymorphism technique. The results showed that individuals with GG genotype in TRF 1 rs3863242 had longer telomere lengths than those with AG + AA genotype in the control group ( p = 0.005). The multiple regression analysis suggested that both omethoate exposure ( b = 0.526, p < 0.001) and TRF 1 rs3863242 GG ( b = 0.220, p = 0.002) were related to a longer telomere length. In conclusion, GG genotype in TRF 1 rs3863242 is linked to prolongation of telomere length, and individuals with GG genotype are recommended to strengthen health protection in a Chinese occupational omethoate-exposed population.