A new diterpenoid alkaloid from Aconitum hemsleyanum. Issue 9 (2nd May 2020)

• Record Type: Journal Article
• Authors: Luo, Zhi-Hui; Chen, Yang; Sun, Xin-Yi; Fan, Hua; Li, Wei; Deng, Liang; Yin, Tian-Peng
• Is Part Of: Natural product research. Volume 34:Issue 9(2020)
• Page Start: 1331
• Page End: 1336
• Publication Date: 2020-05-02
• Subjects: Aconitum hemsleyanum -- Ranunculaceae -- diterpenoid alkaloid -- cholinesterase inhibitory effect; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1560292
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new C19 -diterpenoid alkaloid named hemsleyaline (1 ), along with fourteen known alkaloids (2 -15 ), were isolated from the roots of Aconitum hemsleyanum Pritz. (Ranunculaceae), a herbal medicine in southwest China. Their structures were established on the basis of extensive spectroscopic analyses. Compound 1 showed mild cholinesterase inhibitory effect with IC50 value of 471 ± 9 μM. Graphical Abstract: